Post by Lisa Petrison on Aug 26, 2012 13:00:17 GMT -5
Brain Res Bull. 2010 Apr 29;82(1-2):4-6. Epub 2010 Mar 7.
Fungal toxins and multiple sclerosis: a compelling connection.
Purzycki CB, Shain DH.
Source
Department of Biology, Rutgers, The State University of New Jersey, 315 Penn Street, Camden, NJ 08102, United States. c.purzyc@usp.edu
Abstract
Multiple sclerosis occurs as a consequence of central nervous system neuronal demyelination. Decades of research suggest that the primary suspects (e.g., viruses, genes, immune system) are associative rather than causative agents, but a surprisingly coherent relationship can be made between multiple sclerosis and fungal toxins. Specifically, certain pathogenic fungi sequester in non-neuronal tissue and release toxins that target and destroy CNS astrocytes and oligodendrocytes. Without these glial support cells, myelin degrades triggering the onset of multiple sclerosis and its associated symptoms. We propose here that fungal toxins are the underlying cause of multiple sclerosis and thus may offer an avenue towards an effective cure.
Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 20214953 [PubMed - indexed for MEDLINE]
Fungal toxins and multiple sclerosis: a compelling connection.
Purzycki CB, Shain DH.
Source
Department of Biology, Rutgers, The State University of New Jersey, 315 Penn Street, Camden, NJ 08102, United States. c.purzyc@usp.edu
Abstract
Multiple sclerosis occurs as a consequence of central nervous system neuronal demyelination. Decades of research suggest that the primary suspects (e.g., viruses, genes, immune system) are associative rather than causative agents, but a surprisingly coherent relationship can be made between multiple sclerosis and fungal toxins. Specifically, certain pathogenic fungi sequester in non-neuronal tissue and release toxins that target and destroy CNS astrocytes and oligodendrocytes. Without these glial support cells, myelin degrades triggering the onset of multiple sclerosis and its associated symptoms. We propose here that fungal toxins are the underlying cause of multiple sclerosis and thus may offer an avenue towards an effective cure.
Copyright 2010 Elsevier Inc. All rights reserved.
PMID: 20214953 [PubMed - indexed for MEDLINE]
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